Hypophosphatasia (HPP) may feel different for every patient, but it should never feel unimportant1,2
Ask your patients about how HPP may impact their ability to work, connect, and live independently.
SIGN UP TO LEARN MORE
Head of the Center for Osteoporosis and Metabolic Bone Disease, Cleveland Clinic
img example
Use this tool to help you to recognize and diagnose patients with HPP.
DOWNLOAD
A comprehensive guide to HPP and ALP that includes patient profiles, signs and symptoms, key data on burden of disease, diagnostic criteria, and more.
DOWNLOAD
advance I am a healthcare professional I am not a healthcare professional
SIGN UP TO LEARN MORE
References: 1. Weber TJ, Sawyer EK, Moseley S, Odrljin T, Kishnani PS. Metabolism. 2016;65(10):1522-1530. 2. Durrough C, Colazo JM, Simmons J, et al. Bone. 2021;142:115695. 3. Szabo SM, Tomazos IC, Petryk A, et al. Orphanet J Rare Dis. 2019;14(1):85. 4. Conti F, Ciullini L, Pugliese G. Clin Cases Miner Bone Metab. 2017;14(2):230-234. 5. Yoshida H, Murakami T, Ogawa A, et al. Endocrinol Diabetes Metab Case Rep. 2025;2025(1):e240121. 6. Bangura A, Wright L, Shuler T. Cureus. 2020;12(6):e8594. 7. Kawashima H, Atsuko Sasame, Ogaki Y, Nakayama T. JMAJ. 2025;8(1):204-208. 8. Mornet E, Taillandier A, Domingues C, et al. Eur J Hum Genet. 2021;29(2):289-299. 9. Lefever E, Witters P, Gielen E, et al. J Clin Densitom. 2020;23(3):340-348. 10. Injean P, Tan J, Lee S, Downey C. ACR Open Rheumatol. 2023;5(10):524-528. 11. Labcorp. Accessed April 3, 2023. https://www.labcorp.com/tests/001107/alkaline-phosphatase 12. Mercimek-Mahmutoglu S, Sidky S, Hyland K, et al. Orphanet J Rare Dis. 2015;10:12. 13. Cellini B, Montioli R, Oppici E, Astegno A, Borri Voltattorni C. Clin Biochem. 2014;47(3):158-165. 14. Pierpont EI, Simmons JH, Spurlock KJ, Shanley R, Sarafoglou KM. Orphanet J Rare Dis. 2021;16(1):80. 15. Rockman-Greenberg C. Pediatr Endocrinol Rev. 2013;10 Suppl 2:380-388. 16. Rush E, Brandi ML, Khan A, et al. Osteoporos Int. 2024;35(1):1-10. 17. Peroutka C, Beck NM, Gough E, Marzinke M, Hoover-Fong J. Published online February 26, 2021. 18. Polubriaginof F, Tatonetti NP, Vawdrey DK. AMIA Annu Symp Proc. 2015;2015:2035-2042.